A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy

Yolanda Prezado (1) , Ryochi Hirayama (2) , Naruhiro Matsufuji (2) , Taku Inaniwa (2) , Immaculada Martínez-Rovira (3) , Olivier Seksek (4) , Annaïg Bertho (1) , Sachiko Koike (2) , Dalila Labiod (5) , Frederic Pouzoulet (5, 6) , Laura Polledo , Nils Warfving , Aléthéa Liens , Judith Bergs (7) , Takashi Shimokawa (2)

1 Signalisation, radiobiologie et cancer
2 NIRS - National Institute of Radiological Sciences
3 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
4 IJCLab - Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
5 Université Paris-Saclay
6 Institut Curie [Paris]
7 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]

Background: among all types of radiation, very heavy ions, such as Neon (Ne) or Argon (Ar), are the optimum candidates for hypoxic tumor treatments due to their reduced oxygen enhancement effect. However, their pioneering clinical use in the 1970s was halted due to severe side effects. The aim of this work was to provide a first proof that the combination of very heavy ions with minibeam radiation therapy leads to a minimization of toxicities and, thus, opening the door for a renewed use of heavy ions for therapy Methods: mouse legs were irradiated with either Ne MBRT or Ne broad beams at the same average dose. Skin toxicity was scored for a period of four weeks. Histopathology evaluations were carried out at the end of the study Results: a significant difference in toxicity was observed between the two irradiated groups. While severe da-mage, including necrosis, was observed in the broad beam group, only light to mild erythema was present in the MBRT group Conclusion: Ne MBRT is significantly better tolerated than conventional broad beam irradiations

Mots clés: normal tissue toxicity; hypoxic tumors; heavy ion therapy; Minibeam minibeam radiation therapy

Domaines: Cancer; Médecine nucléaire

Yolanda Prezado, Ryochi Hirayama, Naruhiro Matsufuji, Taku Inaniwa, Immaculada Martínez-Rovira, et al.. A Potential Renewed Use of Very Heavy Ions for Therapy: Neon Minibeam Radiation Therapy. Cancers, 2021, 13 (6), pp.1356. ⟨10.3390/cancers13061356⟩. ⟨hal-03376161⟩