. Dgs, Plan d'action chlordécone en Martinique et en Guadeloupe, 2008.

. Dgs, Bilan par action 2010. Paris: Direction Générale de la Santé, 2008.

. Dgs, Plan d'action contre la pollution par la chlordécone en Guadeloupe et en Martinique 2011-2013. Paris: Direction Générale de la Santé, 2011.

. Invs, Impact sanitaire de l'utilisation du chlordécone aux Antilles françaises Recommandations pour les recherches et les actions de santé publique, 2009.

E. Godard and L. Guldner, Évaluation et gestion du risque alimentaire associé au chlordécone pour les populations de Guadeloupe et de Martinique. Numéro thématique -Chlordécone aux Antilles : bilan actualisé des risques sanitaires, BEH, pp.3-4, 2011.

A. Afssa, Evaluation de l'impact de mesures de maîtrise des risques. final. Maisons-Alfort: Agence Française de Sécurité Sanitaire des Aliments, 2007.

P. S. Larson, E. Jr, J. L. Hennigar, G. R. Lane, R. W. Borzelleca et al., Acute, subchronic, and chronic toxicity of chlordecone, Toxicol Appl Pharmacol, vol.48, issue.1, pp.29-41, 1979.

P. S. Guzelian, Comparative toxicology of chlordecone (Kepone) in humans and experimental animals, Annu Rev Pharmacol Toxicol, vol.22, pp.89-113, 1982.

P. S. Guzelian, The clinical toxicology of chlordecone as an example of toxicological risk assessment for man, Toxicol Lett, pp.589-96, 1992.

E. S. Sobel, F. Wang, E. Butfiloski, B. Croker, and S. M. Roberts, Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F (1) and BALB/c mice, Toxicology, vol.218, issue.2-3, pp.81-90, 2006.

L. Multigner, J. R. Ndong, A. Giusti, M. Romana, H. Delacroix-maillard et al., Chlordecone exposure and risk of prostate cancer, J Clin Oncol, vol.28, issue.21, pp.3457-62, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00518099

R. Dallaire, G. Muckle, F. Rouget, P. Kadhel, H. Bataille et al., Cognitive, visual, and motor development of 7-month-old Guadeloupean infants exposed to chlordecone, Environ Res, vol.118, pp.79-85, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00875939

O. Boucher, M. N. Simard, G. Muckle, F. Rouget, P. Kadhel et al., Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants, Neurotoxicology, vol.35, pp.162-170, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00875907

L. Multigner, P. Kadhel, F. Huc-terki, J. P. Thome, E. Janky et al., Exposure to Chlordecone and Male Fertility in Guadeloupe (French West Indies), Epidemiology, vol.17, issue.6, p.372, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00697382

L. Multigner, P. Kadhel, M. Pascal, F. Huc-terki, H. Kercret et al., Parallel assessment of male reproductive function in workers and wild rats exposed to pesticides in banana plantations in Guadeloupe. Environmental health: a global access science source, vol.7, p.40, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00669505

E. Emeville, F. Giton, A. Giusti, A. Oliva, J. Fiet et al., Persistent organochlorine pollutants with endocrine activity and blood steroid hormone levels in middle-aged men, PLoS ONE, vol.8, issue.6, p.66460, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00876025

. Atsdr, Toxicological profile for mirex and chlordecone. Washington: Agency for Toxic Substances and Disease Registry. US Department of Health and Human Services, 1995.

. Us-epa, Washington: United States Environmental Agency, 2009.

, Report on carcinogenesis bioassay of technical grade chlordecone (Kepone) CAS No. 143-50-0: U.S. Department of health, education and welfare, Public Health Service, 1976.

L. Guldner, L. Multigner, F. Heraud, C. Monfort, J. P. Thome et al., Pesticide exposure of pregnant women in Guadeloupe: ability of a food frequency questionnaire to estimate blood concentration of chlordecone, Environ Res, vol.110, issue.2, pp.146-51, 2010.
URL : https://hal.archives-ouvertes.fr/inserm-00517109

, NRC. Science and decisions. Advancing Risk Assessment, 2009.

. Institute-of-medicine, Cost of Environmental-Related Health Effects: A Plan for Continuing Study. Washington: The National Academies Press, 1981.

R. Melnick, G. Lucier, M. Wolfe, R. Hall, G. Stancel et al., Summary of the National Toxicology Program's report of the endocrine disruptors low-dose peer review, Environ Health Perspect, vol.110, issue.4, pp.427-458, 2002.

S. Cannon, J. J. Veazey, R. Jackson, V. Burse, C. Hayes et al., Epidemic kepone poisoning in chemical workers, Am J Epidemiol, vol.107, issue.6, pp.529-566, 1978.

P. S. Guzelian, G. Vranian, J. J. Boylan, W. J. Cohn, and R. V. Blanke, Liver structure and function in patients poisoned with chlordecone (Kepone), Gastroenterology, vol.78, issue.2, pp.206-219, 1980.

D. W. End, R. A. Carchman, R. Ameen, and W. L. Dewey, Inhibition of rat brain mitochondrial calcium transport by chlordecone, Toxicol Appl Pharmacol, vol.51, issue.1, pp.189-96, 1979.

. Us-epa, Guidelines for Carcinogen Risk Assessment. final, 2005.

S. Greenland, Concepts and pitfalls in measuring and interpreting attributable fractions, prevented fractions, and causation probabilities, Ann Epidemiol, vol.25, issue.3, pp.155-61, 2015.

A. B. Hill, The Environment and Disease: Association or Causation?, Proceedings of the Royal Society of Medicine, vol.58, issue.5, pp.295-300, 1965.

. Us-epa, Benchmark Dose Technical Guidance Document. Final, 2012.

. Us-epa, Benchmark Dose Software (BMDS), 2013.

, The R Foundation. The R Project for Statistical Computing

. Us-epa, Recommended Use of Body Weight 3/4 as the Default Method in Derivation of the Oral Reference Dose. Final, 2011.

. Us-epa, Recommendations for and Documentation of Biological Values for Use in Risk Assessment. Washington: United States Environmental Agency, 1988.

V. Nedellec, Méthodes quantitatives pour évaluer les risques non mutagènes des substances chimiques, 2015.

P. Joly, La saga du chlordécone aux Antilles françaises. Reconstruction chronologique 1968-2008. Document réalisé dans le cadre de l'action 39 du plan chlordécone Convention de collaboration AFSSET -INRA. final: INRA, 2010.

G. H. Ganser and P. Hewett, An accurate substitution method for analyzing censored data, J Occup Environ Hyg, vol.7, issue.4, pp.233-277, 2010.

A. J. Martinez, J. R. Taylor, P. J. Dyck, S. A. Houff, and E. Isaacs, Chlordecone intoxication in man. II. Ultrastructure of peripheral nerves and skeletal muscle, Neurology, vol.28, issue.7, pp.631-636, 1978.

J. R. Taylor, Neurological manifestations in humans exposed to chlordecone and follow-up results, Neurotoxicology, vol.3, issue.2, pp.9-16, 1982.

J. R. Taylor, Neurological manifestations in humans exposed to chlordecone: follow-up results, Neurotoxicology, vol.6, issue.1, pp.231-237, 1985.

J. R. Taylor, J. B. Selhorst, S. A. Houff, and A. J. Martinez, Chlordecone intoxication in man. I. Clinical observations, Neurology, vol.28, issue.7, pp.626-656, 1978.

R. Bolger, T. E. Wiese, K. Ervin, S. Nestich, and W. Checovich, Rapid screening of environmental chemicals for estrogen receptor binding capacity, Environ Health Perspect, vol.106, p.9, 1998.

G. G. Kuiper, J. G. Lemmen, B. Carlsson, J. C. Corton, S. H. Safe et al., Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta, Endocrinology, vol.139, issue.10, pp.4252-63, 1998.

G. Lemaire, W. Mnif, P. Mauvais, P. Balaguer, and R. Rahmani, Activation of alpha-and beta-estrogen receptors by persistent pesticides in reporter cell lines, Life Sci, vol.79, issue.12, pp.1160-1169, 2006.

Y. Li, C. J. Luh, K. A. Burns, Y. Arao, Z. Jiang et al., Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes. Environ Health Perspect, 2013.

P. Thomas and J. Dong, Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: a potential novel mechanism of endocrine disruption, J Steroid Biochem Mol Biol, vol.102, issue.1-5, pp.175-184, 2006.

F. Wu, S. Khan, Q. Wu, R. Barhoumi, R. Burghardt et al., Ligand structuredependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens, J Steroid Biochem Mol Biol, vol.110, issue.1-2, pp.104-119, 2008.

K. Yoon, L. Pallaroni, M. Stoner, K. Gaido, and S. Safe, Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements, J Steroid Biochem Mol Biol, vol.78, issue.1, pp.25-32, 2001.

K. Yoon, L. Pellaroni, K. Ramamoorthy, K. Gaido, and S. Safe, Ligand structure-dependent differences in activation of estrogen receptor alpha in human HepG2 liver and U2 osteogenic cancer cell lines, Mol Cell Endocrinol, vol.162, issue.1-2, pp.211-231, 2000.

J. Baggett, R. L. Klein, H. M. Mehendale, and A. K. Thureson-klein, Acute kepone treatment of rats: a biochemical and ultrastructural study, Pharmacologist, vol.19, issue.2, 1977.

J. E. Chambers and C. A. Trevathan, Effect of mirex, dechlorinated mirex derivatives and chlordecone on microsomal mixed-function oxidase activity and other hepatic parameters, Toxicol Lett, vol.16, issue.1-2, pp.109-124, 1983.

L. R. Curtis, Chlordecone is a potent in vitro inhibitor of oligomycininsensitive Mg2 + ? ATPase of rat bile canaliculi-enriched fraction, J Biochem Toxicol, vol.3, pp.321-329, 1988.

L. R. Curtis and H. M. Mehendale, Hepatobiliary dysfunction and inhibition of ATPase activity of bile canaliculi-enriched fractions following in vivo mirex, photomirex and chlordecone exposures, Toxicol Appl Pharmacol, vol.61, issue.3, pp.429-469, 1981.

D. Desaiah, I. K. Ho, and H. M. Mehendale, Effects of kepone and mirex on mitochondrial Mg2 + ?ATPase activity in rat liver, Toxicol Appl Pharmacol, vol.39, issue.2, pp.219-247, 1977.

D. Desaiah, I. K. Ho, and H. M. Mehendale, Inhibition of mitochondrial Mg2+ ATPase activity in isolated perfused rat liver by kepone, Biochem Pharmacol, vol.26, issue.12, pp.1155-1164, 1977.

D. L. Eaton and C. D. Klaassen, Effects of 2,3,7,8-tetrachloro dibenzo-p-dioxin, Kepone, and poly brominated biphenyls on transport systems in isolated rat hepatocytes, Toxicol Appl Pharmacol, vol.51, issue.1, pp.137-181, 1979.

R. E. Ebel, In Vitro Effects Of Chlordecone (Kepone) On Hepatic Microsomal Cytochrome P-450, Pestic Biochem Physiol, vol.14, issue.3, pp.221-227, 1980.

R. E. Ebel, Alterations in microsomal cytochrome P-450-catalyzed reactions as a function of chlordecone (Kepone) induction, Pestic Biochem Physiol, vol.18, issue.1, pp.113-134, 1982.

D. L. Fabacher and E. Hodgson, Induction of hepatic mixed-function oxidase enzymes in adult and neonatal mice by kepone and mirex, Toxicol Appl Pharmacol, vol.38, issue.1, pp.71-78, 1976.

L. S. Kaminsky, L. J. Piper, D. N. Mcmartin, and M. J. Fasco, Induction of hepatic microsomal cytochrome P-450 by mirex and kepone, Toxicol Appl Pharmacol, vol.43, issue.2, pp.327-365, 1978.

T. A. Kocarek, E. G. Schuetz, and P. S. Guzelian, Selective induction of cytochrome P450e by kepone (chlordecone) in primary cultures of adult rat hepatocytes, Mol Pharmacol, vol.40, issue.2, pp.203-213, 1991.

T. A. Kocarek, E. G. Schuetz, and P. S. Guzelian, Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel, Toxicol Lett, vol.71, issue.2, pp.183-96, 1994.

C. A. Lamartiniere and J. M. Nicholas, Neonatal chlordecone alteration of the ontogeny of sex-differentiated hepatic drug and xenobiotic metabolizing enzymes, Biochem Pharmacol, vol.33, issue.24, pp.4092-4097, 1984.

J. Lee, R. C. Scheri, Y. Zhang, and L. R. Curtis, Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice, Toxicol Appl Pharmacol, vol.233, issue.2, pp.193-202, 2008.

M. Lewandowski, P. Levi, and E. Hodgson, Induction of cytochrome P-450 isozymes by mirex and chlordecone, J Biochem Toxicol, vol.4, issue.3, pp.195-204, 1989.
DOI : 10.1002/jbt.2570040309

B. V. Madhukar and F. Matsumura, Comparison Of Induction Patterns Of Rat Hepatic Microsomal Mixed-Function Oxidases By Pesticides And Related Chemicals, Pestic Biochem Physiol, vol.11, pp.1-3, 1979.

H. M. Mehendale, A. Takanaka, D. Desaiah, and I. K. Ho, Kepone induction of hepatic mixed function oxidases in the male rat, Life Sci, vol.20, issue.6, pp.991-999, 1977.

H. M. Mehendale, A. Takanaka, D. Desaiah, and I. K. Ho, Effect of preexposure to Kepone on hepatic mixed-function oxidases in the female rat, Toxicol Appl Pharmacol, vol.44, issue.1, pp.171-89, 1978.

J. E. Simmons, E. Berman, M. Jackson, and J. Lewtas, In Vitro and In Vivo Toxicity: A Comparison of Acrylamide, Cyclophosphamide, Chlordecone, and Diethylstilbestrol, J Environ Sci Health Part A Environ Sci Eng, vol.7, pp.639-64, 1987.

D. Desaiah and R. B. Koch, Inhibition of ATPases activity in channel catfish brain by Kepone and its reduction product, Bull Environ Contam Toxicol, vol.13, issue.2, pp.153-161, 1975.

L. C. Folmar, In Vitro Inhibition Of Rat Brain ATPase, pNPPase, And ATP-32Pi Exchange By Chlorinated-Diphenyl Ethanes And Cyclodiene Insecticide, Bull Environ Contam Toxicol, vol.19, issue.4, pp.481-489, 1978.

J. D. Doherty, N. Salem, C. J. Lauter, and E. G. Trams, Mn2+ and Ca2+ ATPases in lobster axon plasma membranes and their inhibition by pesticides, Comp Biochem Physiol C, vol.69, issue.2, pp.185-90, 1980.
DOI : 10.1016/0306-4492(81)90127-1

D. Desaiah, T. Gilliland, I. K. Ho, and H. M. Mehendale, Inhibition of mouse brain synaptosomal ATPases and ouabain binding by chlordecone, Toxicol Lett, vol.6, issue.4-5, pp.275-85, 1980.
DOI : 10.1016/0378-4274(80)90132-0

D. Desaiah and C. H. Trottman, Sensitivity of rat brain synaptosomal ATPases to several structurally related organochlorine compounds, Toxicol Lett, vol.5, p.1, 1980.

W. M. Bracken, R. P. Sharma, and S. J. Kleinschuster, The effects of select neurotoxic chemicals on synaptosomal monoamine uptake and K + ?dependent phosphatase, Fundamental and applied toxicology : official journal of the Society of Toxicology, vol.1, issue.6, pp.432-438, 1981.

S. K. Bansal and D. Desaiah, Effects of chlordecone and its structural analogs on p-nitrophenyl phosphatase, Toxicol Lett, vol.12, issue.2-3, pp.83-90, 1982.
DOI : 10.1016/0378-4274(82)90168-0

S. C. Chetty, C. N. Aldous, S. S. Rashatwar, and D. Desaiah, Effect of chlordecone on pH and temperature dependent substrate activation kinetics of rat brain synaptosomal ATPases, Biochem Pharmacol, vol.32, issue.21, pp.3205-3216, 1983.

S. K. Bansal and D. Desaiah, Chlordecone toxicity: effect of withdrawal of treatment on ATPase inhibition, Neurotoxicology, vol.6, issue.3, pp.103-110, 1985.

D. Desaiah, C. S. Chetty, and K. S. Rao, Chlordecone inhibition of calmodulin activated calcium ATPase in rat brain synaptosomes, J Toxicol Environ Health, vol.16, issue.2, pp.189-95, 1985.

R. R. Jinna, J. E. Uzodinma, and D. Desaiah, Age-related changes in rat brain ATPases during treatment with chlordecone, J Toxicol Environ Health, vol.27, issue.2, pp.199-208, 1989.

J. E. Uzodinma and D. Desaiah, Age-Related Changes in Rat Brain ATPases during Treatment with Chlordecone, J Toxicol Environ Health, vol.27, issue.2, pp.199-208, 1989.

W. E. Maier and L. G. Costa, Sodium, potassium-ATPase in rat brain and erythrocytes as a possible target and marker, respectively, for neurotoxicity: Studies with chlordecone, organotins and mercury compounds, Toxicol Lett, vol.51, issue.2, pp.175-88, 1990.

Y. Chang-tsui and I. K. Ho, Effects of Kepone (chlordecone) on synaptosomal g-aminobutyric acid uptake in the mouse, Neurotoxicology, vol.1, issue.2, pp.357-67, 1979.

E. C. Hwang and M. H. Van-woert, Serotonin-norepinephrine interactions in the tremorolytic actions of phenoxybenzamine and trazodone, Pharmacol Biochem Behav, vol.10, issue.1, pp.27-36, 1979.

J. M. Baggett, A. Thureson-klein, and R. L. Klein, Effects of chlordecone on the adrenal medulla of the rat, Toxicol Appl Pharmacol, vol.52, issue.2, pp.313-335, 1980.

Y. Chang-tsui and I. K. Ho, Effect of Kepone (chlordecone) on synaptosomal catecholamine uptake in the mouse, Neurotoxicology, vol.1, issue.3, pp.643-51, 1980.

P. K. Seth, A. K. Agrawal, and S. C. Bondy, Biochemical changes in the brain consequent to dietary exposure of developing and mature rats to chlordecone (kepone), Toxicol Appl Pharmacol, vol.59, issue.2, pp.262-269, 1981.

S. F. Ali, J. S. Hong, W. E. Wilson, J. C. Lamb, J. A. Moore et al., Subchronic dietary exposure of rats to chlordecone (Kepone) modifies levels of hypothalamic beta-endorphin, Neurotoxicology, vol.3, issue.2, pp.119-143, 1982.

K. Fujimori, T. Nabeshima, I. K. Ho, and H. M. Mehendale, Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice, Neurotoxicology, vol.3, issue.2, pp.143-151, 1982.

J. M. Gerhart, J. S. Hong, and H. A. Tilson, The possible sites of chlordecone-induced tremor in rats, Toxicol Appl Pharmacol, vol.70, issue.3, pp.382-391, 1983.

C. N. Aldous, C. S. Chetty, H. M. Mehendale, and D. Desaiah, Lack of effects of chlordecone on synthesis rates, steady state levels and metabolites of catecholamines in rat brain, Neurotoxicology, vol.5, issue.2, pp.59-65, 1984.

O. Gandolfi, D. L. Cheney, J. S. Hong, and E. Costa, On the neurotoxicity of chlordecone: a role for gamma-aminobutyric acid and serotonin, Brain Res, vol.303, issue.1, pp.117-140, 1984.

J. S. Hong, H. A. Tilson, L. L. Uphouse, J. Gerhart, and W. E. Wilson, Effects of chlordecone exposure on brain neurotransmitters: possible involvement of the serotonin system in chlordecone-elicited tremor, Toxicol Appl Pharmacol, vol.73, issue.2, pp.336-380, 1984.

P. M. Hudson, K. Yoshikawa, S. F. Ali, J. C. Lamb, J. R. Reel et al., Estrogen-like activity of chlordecone (kepone) on the hypothalamo-pituitary axis: effects on the pituitary enkephalin system, Toxicol Appl Pharmacol, vol.74, issue.3, pp.383-392, 1984.

D. Desaiah, Chlordecone interaction with catecholamine binding and uptake in rat brain synaptosomes, Neurotoxicology, vol.6, issue.1, pp.159-65, 1985.

J. R. Bloomquist, P. M. Adams, and D. M. Soderlund, Inhibition of gamma-aminobutyric acid-stimulated chloride flux in mouse brain vesicles by polychlorocycloalkane and pyrethroid insecticides, Neurotoxicology, vol.7, issue.3, pp.11-20, 1986.

K. Fujimori, H. Benet, H. M. Mehendale, and I. K. Ho, In vivo and in vitro synthesis, release, and uptake of [3-H]-dopamine in mouse striatal slices after in vivo exposure to chlordecone, J Biochem Toxicol, vol.1, issue.4, pp.1-12, 1986.

H. A. Tilson, P. M. Hudson, and J. S. Hong, 5-Diphenylhydantoin antagonizes neurochemical and behavioral effects of p, p'-DDT but not of chlordecone, J Neurochem, vol.5, issue.6, pp.1870-1878, 1986.

L. Uphouse and K. Eckols, Serotonin receptors in striatum after chlordecone treatment of adult female rats, Neurotoxicology, vol.7, issue.1, pp.25-32, 1986.

R. L. Carr, T. A. Couch, J. Liu, J. R. Coats, and J. E. Chambers, The interaction of chlorinated alicyclic insecticides with brain GABAA receptors in channel catfish (Ictalurus punctatus), J Toxic Environ Health A, vol.56, issue.8, pp.543-53, 1999.

B. Hoskins and I. K. Ho, Chlordecone-induced alterations in content and subcellular distribution of calcium in mouse brain, J Toxicol Environ Health, vol.9, issue.4, pp.535-579, 1982.

H. Komulainen and S. C. Bondy, Modulation of levels of free calcium within synaptosomes by organochlorine insecticides, J Pharmacol Exp Ther, vol.241, issue.2, pp.575-81, 1987.

S. C. Bondy and L. C. Halsall, GM1 ganglioside enhances synaptosomal resistance to chemically induced damage, Neurosci Lett, vol.84, issue.2, pp.229-262, 1988.

S. C. Bondy and H. Komulainen, Intracellular Calcium as an Index of Neurotoxic Damage, Toxicology, vol.49, issue.1, pp.35-41, 1988.

S. C. Bondy and M. Mckee, Prevention of chemically induced synaptosomal changes, J Neurosci Res, vol.25, issue.2, pp.229-264, 1990.

K. Inoue, K. Nakazawa, T. Obama, K. Fujimori, and A. Takanaka, Chlordecone Inhibits Three Types of Ion Channels in a Neural Cell Line, Pharmacol Toxicol, vol.67, issue.5, pp.444-450, 1991.

D. Cheng and M. T. Bedford, Xenoestrogens regulate the activity of arginine methyltransferases, European journal of chemical biology, vol.12, issue.2, pp.323-332, 2011.

N. Benachour, S. Moslemi, H. Sipahutar, and G. E. Seralini, Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination, Toxicol Appl Pharmacol, vol.222, issue.2, pp.129-169, 2007.

C. Bjárge, G. Brunborg, R. Wiger, J. A. Holme, T. Scholz et al., A comparative study of chemically induced DNA damage in isolated human and rat testicular cells, Reprod Toxicol, vol.10, issue.6, pp.509-528, 1996.

V. Caldwell and R. Loch-caruso, Chlordecone rapidly and reversibly inhibits gap junctional communication in human embryonic palatal mesenchyme cells, In Vitro Toxicol, vol.5, issue.2, pp.113-135, 1992.

S. L. Starcevic, S. Bortolin, K. J. Woodcroft, and R. F. Novak, Kepone (chlordecone) disrupts adherens junctions in human breast epithelial cells cultured on matrigel, vol.15, pp.289-94, 2001.

X. Li, S. Zhang, and S. Safe, Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds, J Steroid Biochem Mol Biol, vol.98, issue.2-3, pp.122-154, 2006.

F. I. Ikegwuonu and H. M. Mehendale, Biochemical assessment of the genotoxicity of the in vitro interaction between chlordecone and carbon tetrachloride in rat hepatocytes, J Appl Toxicol, vol.11, issue.4, pp.303-313, 1991.

G. J. Moser and R. C. Smart, Hepatic tumor-promoting chlorinated hydrocarbons stimulate protein kinase C activity, Carcinogenesis, vol.10, issue.5, pp.851-857, 1989.

S. A. Rotenberg and I. B. Weinstein, Two polychlorinated hydrocarbons cause phospholipid-dependent protein kinase C activation in vitro in the absence of calcium, Mol Carcinog, vol.4, issue.6, pp.477-81, 1991.

G. Tsushimoto, J. E. Trosko, C. C. Chang, and F. Matsumura, Inhibition of intercellular communication by chlordecone (kepone) and mirex in Chinese hamster V79 cells in vitro, Toxicol Appl Pharmacol, vol.64, issue.3, pp.550-556, 1982.

N. Clere, E. Lauret, Y. Malthiery, R. Andriantsitohaina, and S. Faure, Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis, Angiogenesis, vol.15, issue.4, pp.745-60, 2012.

H. L. Skalsky, M. W. Fariss, R. V. Blanke, and P. S. Guzelian, The role of plasma proteins in the transport and distribution of chlordecone (Kepone) and other polyhalogenated hydrocarbons, Ann N Y Acad Sci, vol.320, pp.231-238, 1979.

J. A. Rosecrans, J. H. Johnson, H. A. Tilson, and J. S. Hong, Hypothalamic-pituitary adrenal (HPAA) axis function in adult Fischer-344 rats exposed during development to neurotoxic chemicals perinatally, Neurobehav Toxicol Teratol, vol.6, issue.4, pp.281-289, 1984.

J. A. Rosecrans, R. E. Squibb, J. H. Johnson, H. A. Tilson, and J. S. Hong, Effects Of Neonatal Chlordecone Exposure On Pituitary-Adrenal Function In Adult Fischer-344-Rats, Neurobehav Toxicol Teratol, vol.7, issue.1, pp.33-40, 1985.

L. Rosenstein, A. Brice, N. Rogers, and S. Lawrence, Neurotoxicity of kepone in perinatal rats following in utero exposure, Toxicol Appl Pharmacol, vol.41, issue.1, pp.142-145, 1977.

R. E. Squibb and H. A. Tilson, Effects of gestational and perinatal exposure to chlordecone (Kepone) on the neurobehavioral development of Fischer-344 rats, Neurotoxicology, vol.3, issue.2, pp.17-26, 1982.

A. Avis, Agence française de sécurité sanitaire des aliments relatif à l'actualisation des données scientifiques sur la toxicité du chlordécone en vue d'une éventuelle révision des limites tolérables d'exposition proposées par l'Afssa en 2003. final, 2007.

M. D. Reuber, Carcinomas of the liver in rats ingesting kepone, Neoplasma, vol.26, issue.2, pp.231-236, 1979.

. Afssa, Avis de l'Agence française de sécurité sanitaire des aliments relatif à l'évaluation des risques liés à la consommation de denrées alimentaires contaminées par la chlordécone en Martinique et en Guadeloupe. final, 2003.

L. Multigner and P. Kadhel, Exposition à des polluants environnementaux chez la femme enceinte et son enfant en Guadeloupep Niveaux de chlordécone dans le sang maternel et étude des déterminants de l'imprégnation, 2004.

L. Guldner, S. Seurin, F. Héraud, and L. Multignier, Exposition de la population antillaise au chlordécone. Numéro thématique -Chlordécone aux Antilles : bilan actualisé des risques sanitaires BEH, pp.25-33, 2011.

C. Joachim, J. Macni, J. Véronique-baudin, C. Piccotti, and P. Escarmant, Epidémiologie du cancer de la prostate aux Antilles-Guyane : données des registres généraux des cancers, BVS, vol.8, issue.9, pp.3-5, 2013.

A. Giusti, L. Lagadic, A. Barsi, J. P. Thome, C. Joaquim-justo et al., Investigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis, Sci Total Environ, vol.493, pp.147-55, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01123127

S. Wang, J. M. Aarts, L. H. De-haan, D. Argyriou, A. A. Peijnenburg et al., Towards an integrated in vitro strategy for estrogenicity testing, J Appl Toxicol, vol.34, issue.9, pp.1031-1071, 2014.
DOI : 10.1002/jat.2928

S. Bucher, L. Vee, M. Jouan, E. Fardel, and O. , Regulation of hepatic drug transporter activity and expression by organochlorine pesticides, J Biochem Mol Toxicol, vol.28, issue.3, pp.119-147, 2014.
DOI : 10.1002/jbt.21543
URL : https://hal.archives-ouvertes.fr/hal-01063656

L. G. Costa, The neurotoxicity of organochlorine and pyrethroid pesticides, Handb Clin Neurol, vol.131, pp.135-183, 2015.
DOI : 10.1016/b978-0-444-62627-1.00009-3

B. Gaume, N. Dodet, J. P. Thome, and S. Lemoine, Expression of biotransformation and oxidative stress genes in the giant freshwater prawn Macrobrachium rosenbergii exposed to chlordecone, Environ Sci Pollut Res Int, vol.22, issue.11, pp.7991-8002, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01231841

L. Saunders, P. Kadhel, N. Costet, F. Rouget, C. Monfort et al., Hypertensive disorders of pregnancy and gestational diabetes mellitus among French Caribbean women chronically exposed to chlordecone, Environ Int, vol.68, pp.171-177, 2014.
DOI : 10.1016/j.envint.2014.03.024
URL : https://hal.archives-ouvertes.fr/hal-01061391

M. Dieye, R. Banydeen, J. Macni, S. Michel, J. Veronique-baudin et al., Geographic variations and temporal trends in prostate cancer in Martinique over a 25-year period, BMC research notes, vol.7, p.262, 2014.
DOI : 10.1186/1756-0500-7-262
URL : https://hal.archives-ouvertes.fr/inserm-00988476

P. Kadhel, C. Monfort, N. Costet, F. Rouget, J. P. Thome et al., Chlordecone exposure, length of gestation, and risk of preterm birth, Am J Epidemiol, vol.179, issue.5, pp.536-580, 2014.
DOI : 10.1093/aje/kwt313
URL : https://hal.archives-ouvertes.fr/hal-01010740

S. Cordier, E. Bouquet, C. Warembourg, C. Massart, F. Rouget et al., Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: the Timoun cohort study in Guadeloupe (French West Indies), Environ Res, vol.138, pp.271-279, 2015.
DOI : 10.1016/j.envres.2015.02.021
URL : https://hal.archives-ouvertes.fr/hal-01134317

N. Costet, F. Pele, E. Comets, F. Rouget, C. Monfort et al., Perinatal exposure to chlordecone and infant growth, Environ Res, vol.142, pp.123-157, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01169790

W. H. Goodson, L. Lowe, D. O. Carpenter, M. Gilbertson, M. Ali et al., Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead, Carcinogenesis, vol.36, issue.1, pp.254-96, 2015.
URL : https://hal.archives-ouvertes.fr/pasteur-01352152

L. N. Vandenberg, T. Colborn, T. B. Hayes, J. J. Heindel, D. R. Jacobs et al., Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses, Endocr Rev, vol.33, issue.3, pp.378-455, 2012.

F. Wang, S. M. Roberts, E. J. Butfiloski, L. Morel, and E. S. Sobel, Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice, Toxicol Sci, vol.99, issue.1, pp.141-52, 2007.