Large-Scale “OMICS” Studies to Explore the Physiopatholgy of HIV-1 Infection

Abstract : In this review, we present the main large-scale experimental studies that have been performed in the HIV/AIDS field. These "omics" studies are based on several technologies including genotyping, RNA interference, and transcriptome or epigenome analysis. Due to the direct connection with disease evolution, there has been a large focus on genotyping cohorts of well-characterized patients through genome-wide association studies (GWASs), but there have also been several in vitro studies such as small interfering RNA (siRNA) interference or transcriptome analyses of HIV-1-infected cells. After describing the mojor results obtained with these omics technologies-including some with a high relevance for HIV-1 treatment-we discuss the next steps that the community needs to embrace in order to derive new actionable therapeutic or diagnostic targets. Only integrative approaches that combine all big data results and consider their complex interactions will allow us to capture the global picture of HIV molecular pathogenesis. This novel challenge will require large collaborative efforts and represents a huge open field for innovative bioinformatics approaches.
Complete list of metadatas

Cited literature [91 references]  Display  Hide  Download

https://hal-cnam.archives-ouvertes.fr/hal-02308473
Contributor : Aurélie Puybonnieux <>
Submitted on : Tuesday, October 8, 2019 - 3:17:17 PM
Last modification on : Thursday, October 10, 2019 - 5:04:04 PM

File

fgene-10-00799.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Sigrid Le Clerc, Sophie Limou, Jean-François Zagury. Large-Scale “OMICS” Studies to Explore the Physiopatholgy of HIV-1 Infection. Frontiers in Genetics, Frontiers, 2019, 10, pp.799. ⟨10.3389/fgene.2019.00799⟩. ⟨hal-02308473⟩

Share

Metrics

Record views

22

Files downloads

33