Synthesis of amorpha-4,11-diene from dihydroartemisinic acid

Geoffrey Schwertz; Andrea Zanetti; Marllon Nascimento de Oliveira; Mario Andrés Gómez Fernández; Fabienne Dioury; Janine Cossy; Zacharias Amara

doi:10.1016/j.tet.2018.12.050

Journal articles

Synthesis of amorpha-4,11-diene from dihydroartemisinic acid

Geoffrey Schwertz ^{1, 2} Andrea Zanetti ^{1, 2} Marllon Nascimento de Oliveira ^{1, 2} Mario Andrés Gómez Fernández ^{1, 2} Fabienne Dioury ² Janine Cossy ¹ Zacharias Amara ²

1 CBI - Chimie-Biologie-Innovation

2 GBCM - Laboratoire Génomique, bioinformatique et chimie moléculaire

Abstract : Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihy-droartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography.

Domain :

Chemical Sciences / Organic chemistry

Chemical Sciences / Medicinal Chemistry

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Submitted on : Thursday, March 12, 2020 - 5:49:19 PM
Last modification on : Friday, March 13, 2020 - 3:54:17 PM

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Synthesis of amorpha-4,11-diene from dihydroartemisinic acid

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