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Synthesis of amorpha-4,11-diene from dihydroartemisinic acid

Abstract : Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihy-droartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography.
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Submitted on : Thursday, March 12, 2020 - 5:49:19 PM
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Geoffrey Schwertz, Andrea Zanetti, Marllon Nascimento de Oliveira, Mario Andrés Gómez Fernández, Fabienne Dioury, et al.. Synthesis of amorpha-4,11-diene from dihydroartemisinic acid. Tetrahedron, Elsevier, 2019, 75 (6), pp.743-748. ⟨10.1016/j.tet.2018.12.050⟩. ⟨hal-02502402⟩

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