Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization

Marie Devreux (1) , Fabienne Dioury (2) , Céline Henoumont (1) , Clotilde Ferroud (2) , Sophie Laurent (1)

1 UMons - Université de Mons
2 CMGPCE - Laboratoire de Chimie moléculaire, génie des procédés chimiques et énergétiques

Multimodality imaging based on complementary modalities is a way to improve the accuracy of medical diagnoses. For such purpose, multimodal probes combining the appropriate contrastophores into a single delivery are required. The project presented here deals with the combination of two modalities: magnetic resonance imaging (MRI), and photoacoustic imaging (PAI). The dual probe envisaged relies on a pyclen-based gadolinium(III) complex as contrast agent for MRI, together with ZW800-1 fluorophore for PAI, both of them being grafted on a linker derived from Llysine. The results presented here describe the synthetic pathway, and the relaxometric characterization of the dual compound.

Keywords: medical imaging; molecular imaging; multimodality; MRI; photoacoustic; gadolinium; bifunctional chelating agents; pyclen; PCTA12; ZW800-1

Domains: Chemical Sciences; Coordination chemistry; Life Sciences [q-bio]; Bioengineering; Imaging

Marie Devreux, Fabienne Dioury, Céline Henoumont, Clotilde Ferroud, Sophie Laurent. Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization. International Conference on Multidisciplinary Sciences, 4th edition (MOL2NET 2018) - BIOCHEMPHYS-01: International Workshop on Med. Chem., Biotech., and Phys. Chem., 2018, Paris, France. pp.5865, ⟨10.3390/mol2net-04-05865⟩. ⟨hal-03122759⟩