Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization

Abstract : Multimodality imaging based on complementary modalities is a way to improve the accuracy of medical diagnoses. For such purpose, multimodal probes combining the appropriate contrastophores into a single delivery are required. The project presented here deals with the combination of two modalities: magnetic resonance imaging (MRI), and photoacoustic imaging (PAI). The dual probe envisaged relies on a pyclen-based gadolinium(III) complex as contrast agent for MRI, together with ZW800-1 fluorophore for PAI, both of them being grafted on a linker derived from Llysine. The results presented here describe the synthetic pathway, and the relaxometric characterization of the dual compound.