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Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization

Abstract : Multimodality imaging based on complementary modalities is a way to improve the accuracy of medical diagnoses. For such purpose, multimodal probes combining the appropriate contrastophores into a single delivery are required. The project presented here deals with the combination of two modalities: magnetic resonance imaging (MRI), and photoacoustic imaging (PAI). The dual probe envisaged relies on a pyclen-based gadolinium(III) complex as contrast agent for MRI, together with ZW800-1 fluorophore for PAI, both of them being grafted on a linker derived from Llysine. The results presented here describe the synthetic pathway, and the relaxometric characterization of the dual compound.
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https://hal-cnam.archives-ouvertes.fr/hal-03122759
Contributor : Fabienne Dioury <>
Submitted on : Tuesday, March 16, 2021 - 2:01:03 PM
Last modification on : Monday, March 22, 2021 - 3:54:00 PM
Long-term archiving on: : Thursday, June 17, 2021 - 7:32:55 PM

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Marie Devreux, Fabienne Dioury, Céline Henoumont, Clotilde Ferroud, Sophie Laurent. Dual-modality probe for MRI and photoacoustic imaging: synthesis, and relaxometric characterization. International Conference on Multidisciplinary Sciences, 4th edition (MOL2NET 2018) - BIOCHEMPHYS-01: International Workshop on Med. Chem., Biotech., and Phys. Chem., 2018, Paris, France. pp.5865, ⟨10.3390/mol2net-04-05865⟩. ⟨hal-03122759⟩

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