Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort - Cnam - Conservatoire national des arts et métiers Accéder directement au contenu
Article Dans Une Revue Environmental Health Année : 2022

Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort

Jean-Pierre Cravedi
Laurent Debrauwer

Résumé

Background Studies focusing on dietary pesticides in population-based samples are scarce and little is known about potential mixture effects. We aimed to assess associations between dietary pesticide exposure profiles and Type 2 Diabetes (T2D) among NutriNet-Santé cohort participants Method Participants completed a Food Frequency Questionnaire at baseline, assessing conventional and organic food consumption. Exposures to 25 active substances used in European Union pesticides were estimated using the Chemisches und Veterinäruntersuchungsamt Stuttgart residue database accounting for farming practices. T2D were identified through several sources. Exposure profiles were established using Non-Negative Matrix Factorization (NMF), adapted for sparse data. Cox models adjusted for known confounders were used to estimate hazard ratios (HR) and 95% confidence interval (95% CI), for the associations between four NMF components, divided into quintiles (Q) and T2D risk. Results The sample comprised 33,013 participants aged 53 years old on average, including 76% of women. During follow-up (median: 5.95 years), 340 incident T2D cases were diagnosed. Positive associations were detected between NMF component 1 (reflecting highest exposure to several synthetic pesticides) and T2D risk on the whole sample: HR Q5vsQ1 = 1.47, 95% CI (1.00, 2.18). NMF Component 3 (reflecting low exposure to several synthetic pesticides) was associated with a decrease in T2D risk, among those with high dietary quality only (high adherence to French dietary guidelines, including high plant foods consumption): HR Q5vsQ1 = 0.31, 95% CI (0.10, 0.94). Conclusions These findings suggest a role of dietary pesticide exposure in T2D risk, with different effects depending on which types of pesticide mixture participants are exposed to. These associations need to be confirmed in other types of studies and settings, and could have important implications for developing prevention strategies (regulation, dietary guidelines)
Fichier principal
Vignette du fichier
12940_2022_Article_862.pdf (1.41 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03689933 , version 1 (07-06-2022)

Licence

Paternité

Identifiants

Citer

Pauline Rebouillat, Rodolphe Vidal, Jean-Pierre Cravedi, Bruno Taupier-Letage, Laurent Debrauwer, et al.. Prospective association between dietary pesticide exposure profiles and type 2 diabetes risk in the NutriNet-Santé cohort. Environmental Health, 2022, 21 (1), pp.57. ⟨10.1186/s12940-022-00862-y⟩. ⟨hal-03689933⟩
287 Consultations
75 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More