Induction chemotherapy before surgery for unresectable head and neck cancer.
Résumé
Objective: To preoperatively reduce tumour size in patients with locally advanced and/or non-resectable squamous cell carcinoma with induction chemotherapy in order to achieve surgical excision with clear margins and preserve quality of life.
Methodology: In this study, 16 patients with locally advanced and/or non-resectable squamous cell carcinoma underwent induction chemotherapy with docetaxel, cisplatin, and 5-fluorouricil or paclitaxel, carboplatin, and cetuximab.
Results: Over 80% of patients responded to induction chemotherapy. Histological examination of the 14 surgical
specimens showed a total absence of residual cancer cells in 37.5% of cases.
Conclusion: Concurrent radiation and chemotherapy is the standard treatment for locally advanced head and neck squamous cell carcinoma; however, induction chemotherapy may be beneficial in select patients.
Domaines
Cancer
Origine : Fichiers éditeurs autorisés sur une archive ouverte
licence : CC BY - Paternité
licence : CC BY - Paternité