Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: the MEMENTO cohort study

Melina Regy (1, 2) , Aline Dugravot (1) , Severine Sabia (1, 3) , Aurore Fayosse (1) , Jean-Francois Mangin (4, 5, 6) , Marie Chupin (4, 6, 5) , Clara Fischer (5, 4, 6) , Vincent Bouteloup (7, 8, 9) , Carole Dufouil (7, 8, 9) , Genevieve Chene (7, 8, 9) , Claire Paquet (10, 11) , Bernard Hanseeuw (2) , Archana Singh-Manoux (1, 3) , Julien Dumurgier (1, 10)

1 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
2 UCL - Université Catholique de Louvain = Catholic University of Louvain
3 UCL - University College of London [London]
4 CATI - Centre d'Acquisition et de Traitement des Images [Paris] = CATI Multicenter Neuroimaging Platform
5 NEUROSPIN - Service NEUROSPIN
6 BAOBAB - Building large instruments for neuroimaging: from population imaging to ultra-high magnetic fields
7 BPH - Bordeaux population health
8 CHU Bordeaux
9 CIC Bordeaux
10 Hôpital Lariboisière-Fernand-Widal [APHP]
11 OPTeN (UMR_S 1144 / U1144) - Optimisation thérapeutique en Neuropsychopharmacologie

Data on 2,045 non-demented individuals with memory complaints were drawn from the Memento cohort study to examine the association between Apolipoprotein E ε4 allele (APOE4) and regional brain gray matter volumes. Linear regression was used to examine the association of APOE4 and measures of regional gray matter volumes in cross-sectional analysis and change therein using longitudinal analyses based on two brain MRI performed at baseline and at two-year follow-up. Overall, in analyses adjusted for age, sex, and intracranial volume, the presence of APOE4 was associated with lower total gray matter volume at baseline and with a higher atrophy rate over the follow-up. The hippocampus and entorhinal cortex were the two gray matter regions most associated with APOE4. Further adjustment for cardiovascular risk factors had little impact on these associations. There was an interaction between age, APOE4 status and total brain volume atrophy rate, with evidence of an earlier age at onset of atrophy in hippocampal volume in APOE4 carriers compared to non-carriers. Those results are in accordance with the role of medial temporal structures in the greater risk of dementia observed in people carrying the APOE4 allele.

Mots clés: APOE genotype; MRI; Longitudinal analysis

Domaines: Santé publique et épidémiologie

Melina Regy, Aline Dugravot, Severine Sabia, Aurore Fayosse, Jean-Francois Mangin, et al.. Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: the MEMENTO cohort study. NeuroImage, 2022, 250, ⟨10.1016/j.neuroimage.2022.118966⟩. ⟨hal-03606321⟩